Ok, there's a lot of interesting things going on with this one. Interesting and burgeoning with potential, but not without risk.
First off: Seth MacFarlane making the transition to a live-action television comedy. Interesting choice, Seth. Like him or not, Seth's one-man creative partnership with Fox's Sunday night set of animated series is something unprecedented in network history. Most of his humor isn't quite to my taste, but I'll be the first to admit that Family Guy at it's finest has more intelligence and comedic timing than the entire run of other shows currently on television.
But the real question is: will MacFarlane's humor translate well into live-action? It certainly had mixed reviews in his feature film Ted, and Dads is even more firmly grounded in a typical, non-fanciful environment. So, there's going to a be a lot of great gooey material to study in the writing department.
Talent-wise, I think the show is more than solid. This isn't just because Seth Green has been my TV boyfriend since 1998 (Oz 4evah!!), although that certainly contributes. Overall, every single one of the season regulars seems to have a great handle on timing and dialogue. I have no qualms there.
I do have one request that I would like to make to the universe: could the dads please end up having some redeeming qualities/wisdom/show of humanity? Call me old-fashioned, but I wouldn't mind having the occasional episode wrap up with the father and son coming together, recognizing good intentions all around and a need for more empathy in their relationship. Essentially, I'd like Seth MacFarlane to mix a bit more with Leave it to Beaver and My Three Sons. Having the dads be just horrible messes that only bring negativity to their progeny (internal rhyme! so hot!) seems irresponsibly cynical and one-dimensional.